The only thing coming to mind right now is... I-95. If you haven't driven it before, prepare yourself. Your driving attention must be at 100%. It's 2-3 lanes wide (in each direction), bumper to bumper at around 80MPH (except around Washington DC which is like 5MPH). One person touches their brake or makes an unsafe lane change and there's often a chain reaction of drivers behind hitting their brakes at varying degrees which often causes a wreck somewhere in there.
I was going to write that this morning but didn't have time. I have driven to literally every State in the continental US, it was our goal to do that for many years, took us 20 and I-95 is THE worst interstate in the entire US ( second to I-5 in California and I-75 through Atlanta)
I have driven up I-95 so many times when we still lived in Florida, I don't know how many.
If at all possible, avoid it, unless you are not bothered by massive traffic, lots of accidents and bad drivers everywhere.
The worst is from about Fredericksburg to past NYC. All of it is bad
One more comment: I would personally skip Savannah , there is not much there. It's just an old city . We stopped a few times to have lunch, and it took me longer to find a place to park than we spent there. Charleston is much nicer and much more to do. You don't have unlimited amounts of time.
Here is my top 6 , ( but we don't really like large boring cities, don't shop and don't go out to eat much, we like outdoor stuff, historical stuff and some touristy places , so if you don't like that sort of thing ignore my comments)
Charleston/Patriot Point, Smokey Mountain area , Blue Ridge Parkway, Shenandoah . Colonial Williamsburg and Gettysburg
For beach: Virginia Beach or Outer Banks ( but that's time consuming to get to)